BDBM50009859 (+-)-2-(p-isobutylphenyl)propionic acid::(+-)-alpha-methyl-4-(2-methylpropyl)benzeneacetic acid::(+-)-ibuprofen::(+-)-p-isobutylhydratropic acid::(4-isobutylphenyl)-alpha-methylacetic acid::(RS)-ibuprofen::2-(4-isobutylphenyl)propanoic acid::2-[4-(2-methylpropyl)phenyl]propanoic acid::4-isobutylhydratropic acid::Advil::Brufen::CHEMBL521::IBUPROFEN LYSINE::Ibuprofen::Ibuprofen (1)::Motrin::alpha-(4-isobutylphenyl)propionic acid::alpha-(p-isobutylphenyl)propionic acid
SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
InChI Key InChIKey=HEFNNWSXXWATRW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 118 hits for monomerid = 50009859
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataKi: 9.00E+3nMAssay Description:Inhibition of sheep placental cotyledons COX2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataKi: 9.00E+3nMAssay Description:Inhibition of sheep placental cotyledons COX1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataKi: 1.65E+5nMAssay Description:Binding affinity towards human serum albuminMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 4.00E+3nMpH: 8.0Assay Description:Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 8.00E+3nMpH: 8.0Assay Description:Approximately 2 µg of either COX-1 or COX-2 was added to buffer containing 100 µM AA, 0.1 M Tris-HCl buffer (pH 8.0), 5 mM EDTA, 2 mM phenol, and 1 µ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 7.60E+3nMAssay Description:The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.20E+3nMAssay Description:The ability of the test compounds to inhibit ovine COX01 and human recombinant COX-2 was determined using an enzyme immuno assay (EIA) kit according ...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.06E+3nMAssay Description:Reverisible competitive inhibition of prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 1 (COX-1)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+3nMAssay Description:Concentration (in microM) to inhibit 50% of Prostaglandin G/H synthase 1 (COX-1) and is expressed in IC50.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Prostaglandin G/H synthase 1 (COX-1).More data for this Ligand-Target Pair
Affinity DataIC50: 860nMAssay Description:Inhibition of COX-2 in mouse RAW264.7 cells assessed as decrease in LPS-induced PGE2 production treated prior to LPS challenge by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of ovine COX-1 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins prior to substr...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human recombinant COX-2 assessed as decrease in PGH2 production using arachidonic acid as substrate treated with enzyme for 10 mins pri...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 100nMAssay Description:Inhibition activity against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Concentration (in microM) to inhibit 50% of Prostaglandin G/H synthase 2 (COX-2) and is expressed in IC50.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 (COX-2).More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
University of Maryland Hospital
Curated by PDSP Ki Database
University of Maryland Hospital
Curated by PDSP Ki Database
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PGHS1 assessed as conversion of arachidonic acid to prostaglandinMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.01E+4nMAssay Description:Inhibition of purified ovine COX1 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver estera...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of human recombinant COX2 pre-treated for 1 hr before 10-acetyl-3,7-dihydroxyphenoxazin substrate addition in absence of porcine liver est...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:In vitro inhibitory concentration of the compound against COX-2 enzymeMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:In vitro inhibitory concentration of the compound against COX-1 enzymeMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of bovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of bovine COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of ovine COX2 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Faculdade De Ci�Ncias E Tecnologia-Unl
Curated by ChEMBL
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of ovine COX1 by enzyme immuno assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
St. Bartholomew'S and The Royal London School of Medicine and Dentistry
Curated by PDSP Ki Database
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant COX2 by enzyme immuno assayMore data for this Ligand-Target Pair